Alongside Dev Anand and Raj Kapoor, Kumar was one of three big names who dominated the golden age of Indian cinema from the 1940s to the 1960s, enjoying a career spanning more than 50 years and nearly 60 films.
Nicknamed "The Tragedy King" with brooding good looks, tousled hair, and a deep voice, he played the lead in some of the Indian film industry's most commercially successful films of the period.
India's President Pratibha Patil presents The Life Time Achievement award to Dilip Kumar at the 54th National Film Awards Function in New Delhion September 03, 2008.
But he missed out on international fame after famously turning down the chance to play Sherif Ali in David Lean's 1962 classic "Lawrence of Arabia". The part went to then little known Egyptian actor Omar Sharif.
Kumar was born Mohammed Yusuf Khan on December 11, 1922, in Peshawar, Pakistan, then part of British-ruled India. His father was a fruit merchant who took his family to India's entertainment capital in the 1930s.
Dilip Kumar and Amitabh Bachchan attend the 143rd Dadasaheb Phalke Academy Awards 2012 in Mumbai on May 04, 2012
Actress Devika Rani spotted him on his father's fruit stall in then Bombay, leading to a part in his first film, "Jwar Bhata", in 1944.
Rani persuaded him to change his name, so he chose Dilip Kumar, allowing him to hide what he was doing from his disapproving father.
Although "Jwar Bhata" flopped and leading film magazines criticised his performance, Kumar was undeterred and broke through with the 1946 film "Milan".
Among his most remembered roles was the lavish historical romance "Mughal-e-Azam", based on the life of a great Mughal prince. It became one of Bollywood's biggest-grossing films of all time.
Dilip Kumar and his wife Saira Banu pose on the red carpet at the premiere of the Hindi film 'Jab Tak Hai Jaan' in Mumbai on November 12, 2012.
Kumar, who cited Hollywood greats Marlon Brando, Gary Cooper and Spencer Tracy as influences, later won acclaim in 1964 for the nationalistic "Leader", screened against a backdrop of recent wars against China and Pakistan.
The 1970s saw fewer roles, as younger actors like Amitabh Bachchan, now the biggest star in India's hugely prolific Hindi-language cinema industry, took centre stage.
Kumar even took a five-year break after a string of flops, returning in 1981 with the hit "Kranti" (Revolution) and a part alongside Bachchan in "Shakti" (Strength) the following year, plus a string of character roles.
After a series of badly-received films, Kumar took up a more active role in politics in 1998 and worked to end the feuding between India and Pakistan.
Dilip Kumar speaks at the podium for his award for oustanding achievement in Indian cinema at the 5th International Indian Film Academy (IIFA) Awards in Singapore on May 22, 2004.
The same year saw him receive the highest civilian honour in Pakistan, angering Hindu nationalists. Two years later he became a lawmaker for the Congress party.
Kumar credited his successful career to the early days in Peshawar's fabled Qissa Khwani ("Storytellers") Bazaar where travellers would share tales of their adventures.
Efforts are now being made to restore his and other stars' ancestral homes in the Pakistani city as it emerges from years of Islamist militancy that saw cinemas and music shops bombed.
Unlike many actors who appeared in hundreds of films, the versatile Kumar carefully selected roles which by Indian standards only increased his stature in the fiercely competitive industry.
In 2006 he accepted a lifetime achievement award at India's National Film Awards in recognition of his contribution to Indian cinema.
Yet he still admitted that he was baffled at his success.
"Honestly, I've still to figure out how an intensely shy young man called Yusuf Khan became the actor Dilip Kumar," he told The Hindustan Times in an interview to mark his 85th birthday.
Kumar also filed a case in the Supreme Court in the 1990s in support of lesbian love story "Fire" after cinemas were vandalised by Hindu fundamentalist groups.
Kumar married the actress Saira Banu in 1966 when she was 22 years his junior.
Prime Minister Narendra Modi called Kumar a "cinematic legend".
"He was blessed with unparalleled brilliance... His passing away is a loss to our cultural world," Modi tweeted.
Bachchan called him his "idol" while Anil Kapoor said he "was and will always be the finest & greatest actor of our industry for me".
Former Pakistan cricket captain Shahid Afridi said his death was "a huge loss" while animal rights group PETA India said "animals everywhere have lost a great friend".
Preparations were being made for his funeral in Mumbai scheduled for later in the day.