"The United States is invested in building a positive future of the region, in partnership with all of you - and the United States is not going anywhere," Biden told the Arab leaders in a speech to kick off the summit.
Biden is seeking to start a new chapter in U.S. involvement in the Middle East, hoping to move past US military conflicts and instead push for a region that respects individual nations' domestic affairs but seeks economic integration and shared defences amid concerns over Iran.
Biden, on his first Middle East trip as president, has focused on Saturday's planned summit with six Gulf states and Egypt, Jordan and Iraq while downplaying a meeting with Saudi Crown Prince Mohammed bin Salman.